Showing posts sorted by relevance for query drug. Sort by date Show all posts
Showing posts sorted by relevance for query drug. Sort by date Show all posts

Saturday, April 24, 2021

Cure by Jo Marchant

Over my lifetime, I’ve observed an increasing interest in the connection between mind and body. It is not a new concept, but it has gained ground and the Cartesian distinction between mind and body has eroded. However, how we are still learning how it works and the extent to which it is effective in the treatment of disease. Geneticist and science writer Jo Marchant explores these issues in Cure.

Marchant considers three areas in which there appears to be mind-body connections that have promise for use in medical settings. First is the placebo effect. Next, she looks at meditation, biofeedback and hypnosis. Finally, she discusses the effects of our viewpoint, especially how increase or reduce stress.

We are equipped with an internal pharmacy that can reduce or aggravate pain, and it can be triggered by something as vague as our expectations. This placebo affect can be as powerful as drugs at reducing pain and some other symptoms of disease, which can make it difficult to test the effectiveness of drugs. Some physicians are starting to change their minds about the placebo effect. Instead of seeing it as a problem that gets in the way of testing drugs, they are seeing it a potential substitute for drugs. The placebo effect has limitations; it can reduce pain and symptoms, but it does not cure the underlying disease or injury. There is also a nocebo effect, which causes pain and fatigue.

Another interesting effect discussed by Marchant is conditioning of the immune system. In some cases, we can prompt the immune system to have a conditioned response; we can train it. After taking a drug, the immune system can reproduce the response to the drug at lower doses. We can strengthen the conditioning by accompanying the drug with strong rituals; repeating the rituals can produce the response to some degree. This holds some promise for improving the effectiveness of drugs and reducing the dose needed to be effective, especially when a drug as serious side effects. I thought this was fascinating.

Our brain is more connected, and in control, of our bodily functions that we previously realized. Meditation, hypnosis and biofeedback can allow people to exercise control over operations of the body that were previously thought to be automatic or even independent of the brain. This includes pain, blood flow, stress response, heart rate variability and vagal tone.

Relationships also have a profound effect on our health. Strong social connections keep us young, and lack of relationships is harmful to our health. Our own compassion for others can reduce stress hormones and inflammation. When physicians, surgeons, nurses and other health care professionals care for their patients as people, those patients receiving the emotional support experience less pain and longer lives.

Marchant shows there is potential for a new way of doing medicine, or room to reintroduce older practices. By slowing down and showing genuine concern for patients, doctors can multiply the effect of their treatment. Teaching people to slow down and pay attention to their bodies, the people they love and the good things in their lives, we can take advantage of the healing capacities of the mind and body. Medicine can be less about dispensing drugs and more about lifestyle and relationship.

If you’re interested in this book, you may also be interested in

The Beethoven Factor by Paul Pearsall

Change Your Brain Change Your Body by Daniel G. Amen

Descarte’s Secret Notebook by Amir D. Aczel

Ecclesiastes

The Genius in All of Us by David Shenk

I Can Make You Happy by Paul McKenna

I Can Make You Thin by Paul McKenna

Instant Self-Hypnosis by Forbes Robbins Blair

Job

The Last Self-Help Book You'll Ever Need by Paul Pearsall

Overwhelmed by Brigid Schulte

Psalms

The Relaxation Response by Herbert Benson with Miriam Z. Klipper

The Road Less Traveled by M. Scott Peck

The Solution by Lucinda Bassett

Solve for Happy by Mo Gawdat

Suggestible You by Erik Vance

Switch on Your Brain by Caroline Leaf

Take the Leap by Heather McCloskey Beck

Timeless Healing by Herbert Benson with Marg Stark

Writing Down the Bones by Natalie Goldberg

Marchant, Jo. Cure: A Journey into the Science of Mind over Body. New York: Crown, 2016.

Sunday, February 15, 2015

The Innocent Man by John Grisham (audio book)

The Innocent Man by John Grisham (Random House, 2006)

This is the story of the trial of two men for the murder of Debra Sue Carter, a young woman who worked as a waitress in Ada, Oklahoma. Ron Williamson and Dennis Fritz were convicted of a crime they did not commit, and the justice system consumed more than a decade of their lives before minimally correcting its error.

I’m not surprised it took so long to overturn the convictions of these men. I’m surprised it got so far to begin with. The police investigation was very incomplete and shoddy, even for 30 years ago when technology and science played a much lesser role in collecting and analyzing evidence (Grisham strongly suggests the Ada police had ties to drug dealer, including one of the detectives on the case, and that influenced the investigation). The lawyers for the defense were competent, but they were not supplied with the means to mount a good defense for their poor clients. Williamson was clearly mentally ill, but there was never a proper determination of his fitness to stand trial. The evidence was so thin I’m surprised a trial was permitted. They even let a former Ada police chief sit on the jury (admittedly, he was not forthcoming during jury selection, but you would think someone in that small town would have known or pressed the issue more).

I can understand the thirst for answers, especially in a small community where a violent crime captures the public attention. It reminds me of the 2005 conviction here in central Missouri of Ryan Ferguson for the of journalist Kent Heitholt in 2001, when Ferguson was still in high school. The conviction rested on some uncertain eyewitness accounts, possibly influenced by police and prosecutors, and the confession Charles Erickson. There seems to be little evidence against Erickson except his drug-induced loss of memories of the night of the crime. He took a plea bargain to testify against Ferguson. As with Williamson, police and courts seemed to pay little attention to the mental state of Erickson.

In spite of the lack of evidence to back up the witnesses few, in my mind Erickson is a very sketchy witness even to his own involvement, the jury convicted Ferguson. People wanted answers, order, justice, and a sense that the issue was resolved so they could return to a safe life. This made them blind to all the problems with the case against Ferguson. The police felt those public pressures and were too ready to go with a problematic case rather than go through a tough investigation that might lead to no answers. The case had other problems, and as people began to admit to false confessions and prosecutorial influence of witnesses, the conviction was revisited and overturned in 2013, after Ferguson had spent most of his 20s in prison.


I think our justice system is often close to the mark and produces mostly good results. However, it should not take years, or decades, to correct such problematic cases as these. In fact, these cases should have never come to trial based on such flimsy evidence.

Tuesday, July 6, 2010

The Dain Curse by Dashiell Hammett

Hammett, Dashiell. The Dain Curse.

The bearer of the Dain Curse described herself as being in a fog, grasping for something solid to hold on to, but finding that everything fades just as it comes within reach. Her morphine addiction might have had something to do with that.

The Continental Op, Hammett’s nameless protagonist, argues that everyone is that way. Everybody is grasping in the fog, piecing together wisps of reality from what they can pick out. He makes a similar argument earlier in the book when he avoids the truth he’d like to find and settles for a story that explains the few things he knows.

I felt like I was in a fog as I read the book. Hammett seemed to wrap up an interesting little pulp mystery, but two-thirds of the book was ahead of me. Every new clue unraveled the ties I’d made. The explanations I’d accepted no longer fit. I was reeling, as dizzy as the drug addled and insane characters in the book.



Even so, I anticipated the identity of the criminal before it was revealed. I didn’t do this through the careful accumulation of clues or rigorous reasoning. I came to me by intuition and some sense of the story’s structure. I suspected this is how the Continental Op must have worked it out, too. He stumbled upon what must have been and tied it all together with a neat explanation afterward.

Dashiell Hammett also wrote
Red Harvest
The Thin Man

If you’re interested in this book, you may also be interested in
The Big Sleep by Raymond Chandler
The Hunter adapted by Darwyn Cook
Will Eisner's The Spirit by Darwyn Cook

Saturday, May 7, 2016

Reckless by Chrissie Hynde

As I get older, I start noticing some strange connections. If Peter Parker aged naturally, he’d be the same age as my father. I also learned that Chrissie Hynde, lead singer of the Pretenders (one of my favorite bands), is only three years younger than my parents. I can hardly believe it, though there is an unreliable part of my mind that seems convinced that I’m still in my early 20s.

This bit about Hynde’s age is hardly the most interesting thing in her autobiography, Reckless. You find many things you normally find in autobiographies. For instance, her early childhood in Ohio was surprisingly and pleasantly normal.

Things get more interesting in her teen years. She became a teenager in the 1960s and she was swept up into the youth culture of the time. She had two loves, music and drugs.

Hynde did a lot of drugs. She doesn’t dwell on the term addiction, but she doesn’t hide that she clearly was addicted. She subjected to herself to may dangers and abuses for the sake of getting high. A person would not do that if she was thinking straight, but addicts don’t think straight.

Unfortunately, drugs got in the way of the music. Drugs took the lives of many innovative musicians of the 1960s and 1970s, and Hynde mentions many of them that she knew. Two members of the Pretenders, Jimmy Scott and Pete Farndon, died of drug-related causes. It seems that there are several occasions in her story, before the Pretenders, when her dream of being in a band was interrupted by drugs, either her own pursuit of them or her potential bandmates’.

Hynde was adventurous. She traveled far from her childhood home in Akron to Canada, Mexico and France before settling in London. London became her home, largely because of the music scene. There she finally put together a band, though an unusual British band with an American lead. She met an amazing number of other musicians, famous then or later, who were there. It may seem like name dropping to discuss the Clash or the Sex Pistols, but these were people she knew and she lived their ups and downs with them.

The final section of the book, covering the career of the Pretenders, is surprisingly short. Admittedly, the original line-up did not last long due to the deaths of Scott and Farndon.

Hynde’s tone is not nostalgic. She has nostalgia for a Midwestern urbanism that was almost dead by the time she came along. She speaks frankly about her own days. She expresses a strong sense of agency and does not blame anyone for the way they treated her or depict herself as a victim. She seems to regret that the drugs people thought would set them free did not, and that as addicts they kept using drugs long after they knew it was a trap.

If you’re interested in rock and roll (and rhythm and blues and punk), you’ll likely enjoy this book. Hynde clearly loves this music and was around when it was undergoing much innovation. She was friends with some of the first stars of punk. He story is also an interesting section of the 1960s and 1970s. For instance, she was a student at Kent State University and witnessed the protests and other events that led to the National Guard firing on students.

If you’r interested in this book, you may also be interested in


Hynde, Chrissie. Reckless: My Life as a Pretender. New York: Doubleday, 2015.

Sunday, April 25, 2021

Happiness is a Choice by Frank B. Minirth and Paul D Meier

I’ve been reading a lot about anxiety and depression lately, and it has led me to some older books, such as Happiness is a Choice by psychiatrists Frank B. Minirth and Paul D. Meier. The book appears to be written for a mixed audience of therapists who may be treating patients with depression and people who may pick up the book as a self-help guide. If depression is affecting your life, I recommend you talk to your physician or reach out for appropriate counseling; there are effective therapies and in some cases drugs may be appropropriate.

The book may be broken into three major parts. The first deals with the symptoms of depression. Though it is fairly widely know now (thanks largely to drug advertising), it was probably less known in 1978 when this book was published, that there are physical symptoms to depression. Feeling bad emotionally can make us feel bad physically and vice-versa.

The second part deals with the causes of depression. These are particularly stress and trauma. We all face trauma in life, and it does not have to be “major” to result in depression. We all grieve losses, get angry over the way we or others are mistreated, face dysfunction in relationships and countless other stresses and traumas. Any of us may suffer a blow that leads to depression.

“Who gets depressed? At some period of life, nearly everyone does!” Frank B. Minirth and Paul D. Meier, Happiness is a Choice

Finally, they deal with the treatment of depression. Much of Minirth and Meier’s advice deals with thinking and relationships. Therapy may occur at a counselor’s office, but healing takes place in everyday life, thoughts and relationships.

The book also contains appendices that deal with things that may be of more interest to therapist. These include a few very brief case studies, a short chapter on the biology of depression and additional information on various types of treatment.

Minirth and Meier are known as Christian counselors who discuss faith alongside medicine. This book is no exception. The authors reference the Bible and draw lessons from it. Though many may find useful advice in this book, I think it would especially appeal to Christian who are seeking help that is consistent with their faith. Their advice on overcoming depression and anxiety is rooted in their religion.

If you’re interested in this book, you may also be interested in

Anxious for Nothing by Max Lucado

The Mindful Way through Depression by Mark Williams, John Teasdale, Zindal Segal & Joh Kabat-Zinn

Rewire Your Anxious Brain by Catherine M. Pittman & Elizabeth M. Karle

The Solution by Lucinda Bassett

Think 4:8 by Tommy Newberry & Lyn Smith

12 “Christian” Beliefs That Can Drive You Crazy by Henry Cloud & John Townsend

Minirth, Frank B., and Paul D. Meier. Happiness is a Choice: A Manual on the Symptoms, Causes and Cures of Depression. Grand Rapids, MI: Baker House, 1978.

Thursday, January 1, 2009

Case Closed (Vol. 2) by Gosho Ayoama

Gosho Ayoama. Case Closed. Vol. 2. 1994. San Francisco: VIZ, 2004.

Case Closed is a collection of short detective stories in comic form (manga). They were originally published in Japan under the title “Meitantei Conan” (Detective Conan). That is the straightforward part.

The hero is a teenager with a genius for solving crime, Jimmy Kudo. He stumbles onto something and a crime organization poisons him. Instead of killing him, the drug shrinks him down to the size of a first grader. He commits himself to finding the men who did it. To protect himself and his friends for the criminals who think he is dead, he takes on the name Conan Edogawa (from mystery authors Conan Doyle and Rumpo Edogawa) and takes up with his unsuspecting girlfriend, Rachel, and her father, mediocre private investigator Richard Moore. To get this back-story, you’ll need to read the first volume or see early episodes of the anime series that closely follows the manga.



Other than that, the stories are straightforward tales of ratiocination in the Western tradition started by Edgar Allen Poe and taken up so well by Doyle in his Sherlock Holmes stories. For someone interested in getting familiar with manga, Japanese comics, this may be a good place to start. The mystery story is familiar to Westerners and the art is in the manga style.

This particular volume has three stories. Gosho Ayoama’s method is to present a complete mystery story and occasionally include stories that touch on Jimmy’s broader quest to return to his normal size and bring his shrinkers to justice. You don’t have to be invested in the larger story to enjoy reading the individual mysteries.

Though Jimmy appears to be a young child, and has adventures with kids from his elementary school class, the stories are not for children. There is murder and other crimes, violence and gore, and children in imminent danger. Conan has a particular knack for provoking killers into coming after him.

Friday, October 8, 2010

Change Your Brain Change Your Body by Daniel G. Amen

Amen, Daniel G. Change Your Brain Change Your Body: Use Your Brain to Get and Keep the Body You Have Always Wanted. New York: Harmony Books, 2010.


Psychiatrist Daniel G. Amen explores the brain-body connection in his medical practice and in this book. In particular, Change Your Brain Change Your Body focuses on how taking care of the health of your brain can result in better health for your entire body.

In the early chapters of the book, Amen makes the case for brain health and how it can affect the health of the rest of the body. This is enhances by images from SPECT scans, which Amen uses in his practice to measure activity in different parts of the brain.

The subtitle of the book touts the brain as a means to get “the body you’ve always wanted.” For me, that includes getting my weight under control, and several chapters are devoted to the subject. There is no escaping a good diet and exercise, both of which get a chapter. What Amen adds is that an understanding of how one’s brain works can help on curb cravings and address brain deficiencies that may be roadblocks to sticking to a weight loss program. By addressing problems in the brain, one becomes more able to address problems with weight.

Good health is more than proper weight. It includes the skin, heart and glands. Good health is also a full life, which includes relationships, the ability worthy pursue worthy goals and the capacity to remember and savor our experiences. Each of these issues is addressed.

Amen doesn’t prescribe a single solution for everyone. Depending on your brain issues, the solution may be as simple as diet and exercise, it may include supplementation or even particular medications or therapies. Obviously, medical interventions should only be undertaken with the supervision of a physician and you should supplementation and physical fitness programs with yours.

The book doesn’t stick too close to traditional medicine. Amen thinks nutritional supplements can be useful and can reduce reliance on medications, but supplements can have issues of drug interaction and side effects that should be covered with a physician. He suggests meditation for stress management and has used hypnosis in his practice to address several issues including weight loss. (For those interested in meditation, Amen recommends The Relaxation Response by Herbert Benson. Hypnosis is recommended in other weight loss books including I Can Make You Thin by Paul McKenna, which includes a self-hypnosis CD.)

In some ways, the book could say change your body change your brain. Many of Amen’s recommendations, especially related to diet and exercise are good recommendations for physical health. Throughout the book, he says that what is good for the heart is good for the brain. He even mentions a study that shows that physically active children perform better academically.

If your interested in this book, you may also be interested in
The Emotional Energy Factor by Mira Kirshenbaum
How Much Does Your Soul Weigh? by Dorie McCubbrey
I Can Make You Thin by Paul McKenna
Instant Self-Hypnosis by Forbes Robbins Blair
The Relaxation Response by Herbert Benson with Miriam Z. Klipper

Sunday, September 23, 2018

Why Comics? by Hilary Chute


I enjoyed reading comic books as a kid. Sometimes I enjoy reading them as an adult. Comics have always been for adults (and kids, too). While popular superhero comics have told stories of the physical and moral paragons of our fantasies, comics have also been a place accessible to those who didn’t see themselves represented in other media. The combination of words and pictures, sometimes more of a juxtaposition, that are the language of comics can powerfully present a point of view. Hilary Chute considers the power of comics to communicate the experience of individuals and subcultures in Why Comics?

While Chute focuses on comic books, she considers cartooning more broadly, especially the early cartoons that appeared in British magazines (quickly imitated in the U.S.) and the American newspaper comic strip. While some newspaper comics were designed to appeal to kids, many were meant to attract adult readers. They often depicted people from poor and immigrant communities. In addition, cartooning could also be very artistic and even in the early days of comic strips some artists were recognized for the quality of their images and storytelling, such as Winsor McCay and George Herriman.

Because Chute generally focuses on groups that were historically or currently marginalized, much of the book focuses on underground and independent comics. I’ll admit that I’ve not particularly been a fan of underground comics. My earliest introduction to underground comics in the 1980s was mostly to 1960s and 1970s books that featured drug culture and bizarre or pornographic depictions of sex. In the subsequent years, I’ve come across some incredibly good underground, literary or artistic comics. Chute discusses some of them such as Art Spieglman’s Maus, Marjane Satrapi’s Persepolis and Harvey Pekar’s American Splendor. I’m a Midwesterner and I was amazed to see Pekar’s depictions of scenes I might see in my own town.

Comics were born as a mass media, which may explain some of the stigma attached to them, and mainstream comics have always been produced in factory-like manor with a division of labor (writer, penciler, inker, etc.). Some creators were uncredited, or one name appeared on the work of many (this practice was common in the newspaper comic strips, too). Undeground and art comics were more often the work of an auteur, who produced the entire work. This opened up comics to more individual perspectives that strayed farther from the mainstream. Comics can powerfully represent personal experience or memories because it is like memory: it mixes words and images, it can readily present comparisons and contrasts, and it can show past, present, future, real and imagined on the same page.

I don’t plan on adding a lot of underground comics to my reading list, but I did enjoy Chute’s book. If someone is looking for an introduction to comics that are outside the mainstream and done well, Why Comics? is a good place to start.

If you’re interested in this book, you may also be interested in

Chute, Hilary. Why Comics?: From Underground to Everywhere. New York: Harper, 2017.